Quinolones are well known for their antibacterial properties, differently substituted quinolones have been synthesized in the present research work by cyclization of parasubstituted aniline with diethylethoxymethylene malonate followed by alkaline hydrolysis and evaluated to explore the effect of substitution at different sites on the antibacterial activity. The present study was done to exploring the effect of different subtituents at 6 and 8 positions on the antibacterial activity. It was found that by substitution at 6 and 8 positions there is improvement in antibacterial activity. The compound B was found to be most effective against E.coli and b.subtillus in comparison to the standard drug at concentration 2µg/ml, 8µg/ml. The compound A was found to be least effective against E.coli and b.subtillus in comparison to standard drug .Antibacterial activity was evaluated by finding minimum inhibitory concentrations (MICs) of antibacterial agents by agar dilution method.
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